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Motorists are facing "10-mile queues" near the Dartford Crossing following a collision between two lorries.
One lane was closed on the M25 anticlockwise between J1b, for the A225 and Princes Road, in Dartford, causing congestion on the route which was already hampered by Easter traffic.
Highways England confirmed all lanes reopened at around 4.45pm, but residual delays remain.
Police were contacted for further information.
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