Traffic was brought to a halt on the A2 due to a crash involving a lorry and three cars near Bluewater.
The incident happened on the coastbound carriageway just before the B225 exit for Bean and the Greenhithe shopping complex.
One vehicle reportedly overturned.
Police and traffic officers attended the scene where no injuries were reported.
The carriageway was closed while arrangements were made to recover the vehicles and it was reopened at around 4.15pm.
However, one lane remains closed due to repairs required on a barrier.
The incident caused large amounts of congestion with long tailbacks stretching back five miles on the approach towards Bexley.
Traffic was also queuing near the Dartford Crossing following a broken down van on an exit slip road on the M25 clockwise at junction 1A near Bob Dunn Way.
As of 7.50pm, National Highways is reporting there are now no delays.
A planned full closure on the A2 coastbound, from the Dartford Bypass to the Bean interchange, is set to come into force from 10pm until 5am tomorrow morning.
More as we get it.