Hythe upset Tonbridge in the FA Trophy on a day when Ramsgate hit nine at the top of Isthmian South East.
Steve Watt’s Cannons bridged a gap of two divisions and 46 places to beat National South Angels on penalties in a second-round tie at Reachfields.
The match went straight to spot-kick after a goalless 90 minutes, with Isthmian South East Hythe winning the shoot-out 3-1 to reach round three for the first time in their history.
Cannons keeper Steve Phillips denied Sean Shields, Tariq Hinds and Francis Mampolo, while Johan Caney-Bryan, Jake Embery and Frannie Collin - who scored the winner - were the successful Hythe takers.
Cray Valley bowed out after losing 5-1 at home to in-form National South side Hampton & Richmond.
Kyrell Lisbie scored a late consolation as the Millers returned to action four days on from their FA Cup First-Round replay against Charlton.
Gary Lockyer gave Cray Wanderers a first-minute lead at Weston but the National South side recovered to win 4-1.
Ramsgate moved three points clear in Isthmian South East after thumping Phoenix Sports 9-1.
Joe Taylor scored four times as Ben Smith’s side chalked up a ninth successive league win.
There were two goals for Benny Bioletti, with Medy Elito, recent signing Craig Stone and Alfie Paxman also on target for the rampant league leaders.
Sittingbourne thrashed Three Bridges 4-1 in a fourth v second meeting at Woodstock.
Defender Joe Tyrie - back with the Brickies after turning out for parent club Tonbridge in midweek - opened the scoring.
The visitors levelled but Jean-Baptiste Fischer’s second-half double and a late Chris Harris goal earned the points as Bourne moved up to third.
Herne Bay climbed back into the play-off places, rising from seventh to fourth, after beating Littlehampton 4-1.
Harrison Pont and Theo Osinfolarin gave Steve Lovell’s side a 2-1 lead at the break, with late goals from Mo Kamara Frankie Smith completing a good day’s work.
Noah Carney scored a last-minute winner as Ashford came from two down to beat Kent rivals Sheppey 3-2 at Homelands.
Alex Willis and James Bessey-Saldanha struck inside 13 minutes for the visitors.
Ian Draycott launched the comeback and Harvey Brand levelled before the break, with Carney pouncing at the death.
Sevenoaks began life under new boss Mark Dacey with a 2-2 draw at home to Merstham.
Dacey - stepping up from assistant manager following Harry Hudson’s resignation - looked set to start with a win after goals from Rowan Liburd and Fumnaya Shomotun but Merstham levelled in the last minute.
Managerless Folkestone lost 3-1 at Dulwich Hamlet in the Isthmian Premier.
The visitors, with player Andy Drury in caretaker charge, trailed inside three minutes.
Kane Penn replied after Hamlet’s second goal but the hosts completed the scoring before half-time.
Margate conceded the only goal at Wingate & Finchley on the stroke of half-time.