More closures of the M2 slip-road and A249 have been announced as work continues on the multi-million pound Stockbury flyover project.
Oad Street, which was last closed at the end of March, will be fully closed between Pett Lane and the A249 and the London-bound exit on to M2 junction 5 will also be closed overnight on Wednesday.
When the road reopens on Thursday, Maidstone-bound traffic leaving the Stockbury roundabout on the A249 will now have to use the new Oad Street link.
Motorists have been told to "just follow the signs".
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A spokesman said: "There will be no right turn from the Oad Street junction on to the northbound A249.
"To join the Sheppey-bound carriageway, turn left, go to M20 junction 7 and the return on the A249 Sheppey-bound.".
From 9pm tonight until 5am tomorrow the A249 Sheppey-bound between the M20 junction 7 and Stockbury roundabout will also be closed overnight while a new temporary barrier is installed.
Then, from 9pm on Wednesday, April 12, until 5am on Thursday, April 13, the A249 Maidstone-bound, between Stockbury roundabout and M20 junction 7, will be closed overnight while National Highways are carrying out line painting and moving traffic to a new link road.
A different part of the road, both Sheppey and Maidstone-bound between Bobbing and the Stockbury roundabout, is also shut from 8pm tomorrow until 5am on Thursday, April 13.
There will also be a closure from 8pm on Thursday, April 13, until 5am on Friday, April 14.
National Highways confirmed a lane will remain open while this takes place.
The closures come after Nation Highways cancelled weekend works at the beginning of the month due to bad weather.
A spokesman said: "Work is progressing well and we’re now preparing to move southbound traffic onto the new Oad Street link road while we carry out work on the A249 carriageway."